Glucocorticoid inhibition of transcription from episomal proopiomelanocortin gene promoter.

@article{Charron1986GlucocorticoidIO,
  title={Glucocorticoid inhibition of transcription from episomal proopiomelanocortin gene promoter.},
  author={Jean Charron and Jacques Drouin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 23},
  pages={8903-7}
}
Glucocorticoid hormones alter transcription of specific genes. Glucocorticoid-stimulated genes have been especially useful in unraveling molecular events responsible for positive gene regulation in mammals. The gene encoding proopiomelanocortin (POMC), which is under feedback inhibition by glucocorticoids, provides a model system to study negative gene regulation. Using an episomal bovine papilloma virus vector, we now demonstrate that a 769-base-pair fragment containing the rat POMC promoter… CONTINUE READING

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