Glucocorticoid inhibition of transcription from episomal proopiomelanocortin gene promoter.

  title={Glucocorticoid inhibition of transcription from episomal proopiomelanocortin gene promoter.},
  author={Jean Charron and Jacques Drouin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={83 23},
Glucocorticoid hormones alter transcription of specific genes. Glucocorticoid-stimulated genes have been especially useful in unraveling molecular events responsible for positive gene regulation in mammals. The gene encoding proopiomelanocortin (POMC), which is under feedback inhibition by glucocorticoids, provides a model system to study negative gene regulation. Using an episomal bovine papilloma virus vector, we now demonstrate that a 769-base-pair fragment containing the rat POMC promoter… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…