Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation.

@article{Phillips2006GlucocorticoidinducedOI,
  title={Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation.},
  author={Jennifer E. Phillips and Charles A Gersbach and Abigail M Wojtowicz and Andr{\'e}s J Garc{\'i}a},
  journal={Journal of cell science},
  year={2006},
  volume={119 Pt 3},
  pages={581-91}
}
Glucocorticoid hormones have complex stimulatory and inhibitory effects on skeletal metabolism. Endogenous glucocorticoid signaling is required for normal bone formation in vivo, and synthetic glucocorticoids, such as dexamethasone, promote osteoblastic differentiation in several in vitro model systems. The mechanism by which these hormones induce osteogenesis remains poorly understood. We demonstrate here that the coordinate action of dexamethasone and the osteogenic transcription factor Runx2… CONTINUE READING
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