Corpus ID: 11593691

Glucocorticoid-induced lymphocytolysis is not mediated by an induced endonuclease.

@article{Alnemri1989GlucocorticoidinducedLI,
  title={Glucocorticoid-induced lymphocytolysis is not mediated by an induced endonuclease.},
  author={Emad S. Alnemri and Gerald Litwack},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 7},
  pages={
          4104-11
        }
}
  • Emad S. Alnemri, Gerald Litwack
  • Published in
    The Journal of biological…
    1989
  • Biology, Medicine
  • The mechanism of glucocorticoid-induced internucleosomal DNA cleavage and cytolysis of lymphatic cells is not known. Recent data (Compton, M.M., and Cidlowski, J.A. (1987) J. Biol. Chem. 262, 8288-8292) suggested that in vivo treatment of rat thymocytes with glucocorticoids induces a nucleolytic "lysis gene" product(s) responsible for lymphocytolysis. In this paper, the possibility that lymphocytolysis may result from glucocorticoid-induced nuclease(s) was examined. Using the rat thymocytes as… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 20 CITATIONS

    Binding of a 23 kD endonuclease to the rat liver nuclear matrix.

    VIEW 6 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents.

    VIEW 6 EXCERPTS
    CITES RESULTS & BACKGROUND
    HIGHLY INFLUENCED

    Apoptosis induced by anticancer drugs

    VIEW 3 EXCERPTS
    CITES BACKGROUND

    Dexamethasone induces apoptosis in human T cell clones expressing low levels of Bcl-2

    VIEW 1 EXCERPT
    CITES BACKGROUND

    References

    Publications referenced by this paper.
    SHOWING 1-8 OF 8 REFERENCES

    Steroid and Sterol Hormone Action (Spelsberg

    • C. E. Reker
    • 1987

    Glucocorticoid Hormone: Mechanisms of Action (Sakamoto, Y., and Isokashi, F

    • J T., G. Litwack
    • 1986

    Steroid Hormone Resistance

    Biochemical Actions of Hormones (Litwack

    • S. Bourgeois, Gasson, C J.
    • G., ed)
    • 1985

    Cell death in biology and pathology

    Cancer Res . 37 , 82888292 46 , 24572462 1 , 899907 37853791 ’ ( 1951 )

    • B. ThomDson.E.
    • J . Biol . Chem .
    • 1977

    68 , 12691273 243 , 14851497 Oncol . 18 , 10931098 2 4 1 , 16461648 Cancer Res . 32 , 350355 18 , 691698 72957303 Res . 33 , 203211 Biochem . 12 , 231243 Cancer Res . 33 , 28732877 Physiol .

    • Y. Sakamoto, F. Isokashi
    • J . Zmmunol . Acad . Sci . U . S . A .
    • 1973