Glucocorticoid-induced inhibition of osteoblastic bone formation in ewes: A biochemical and histomorphometric study

@article{Chavassieux1993GlucocorticoidinducedIO,
  title={Glucocorticoid-induced inhibition of osteoblastic bone formation in ewes: A biochemical and histomorphometric study},
  author={Pascale M. Chavassieux and Philippe Pastoureau and Marie Claire Chapuy and Pierre Dominique Delmas and Pierre Jean Meunier},
  journal={Osteoporosis International},
  year={1993},
  volume={3},
  pages={97-102}
}
The mechanisms underlying glucocorticoid-induced osteoporosis in humans are a defect in bone formation associated with increased bone resorption. The latter may be due to elevated parathyroid hormone (PTH) levels induced by the impairment of intestinal calcium absorption caused by corticosteroids. In this study we analysed the effects of corticosteroids in old ewes, a potential model for the study of human bone turnover. Two groups of seven 9-year-old female sheep were selected. The first group… CONTINUE READING

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Histomorphometric profile, pathophysiology and reversibility of corticosteroidinduced osteoporosis

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