Glucocorticoid-induced impairment in declarative memory performance in adult humans

  title={Glucocorticoid-induced impairment in declarative memory performance in adult humans},
  author={J C Newcomer and Suzanne Craft and Tamara Hershey and K Askins and Megan Elyse Bardgett},
  booktitle={The Journal of neuroscience : the official journal of the Society for Neuroscience},
Glucocorticoids (GCs) have a variety of effects on the brain including site-preferential, inhibitory effects on hippocampal neurons. In the case of dexamethasone (DEX), extended rather than single-dose treatment in vivo may be required for binding to brain rather than peripheral (e.g., pituitary) GC receptors and for maximizing other biologic effects in hippocampus (e.g., GC receptor downregulation, inhibition of glucose transport). Based on the contributory role of hippocampal neurons in… 

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