Glucocorticoid-induced granulocytosis: contribution of marrow release and demargination of intravascular granulocytes.

@article{Nakagawa1998GlucocorticoidinducedGC,
  title={Glucocorticoid-induced granulocytosis: contribution of marrow release and demargination of intravascular granulocytes.},
  author={Mayumi Nakagawa and Takeshi Terashima and Yulia D'yachkova and Gregory P Bondy and James C. Hogg and Stephan F. van Eeden},
  journal={Circulation},
  year={1998},
  volume={98 21},
  pages={2307-13}
}
BACKGROUND Glucocorticoid-induced granulocytosis has been attributed to enhanced release of polymorphonuclear leukocytes (PMNs) from bone marrow, delayed apoptosis, and reduced egress of PMNs into tissues. This study was designed to determine the relative contributions of PMNs released from the bone marrow and those entering the circulation from the marginated pool to the granulocytosis produced by a single dose of dexamethasone (2.0 mg/kg) in rabbits. METHODS AND RESULTS PMN transit through… CONTINUE READING

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