Glucocorticoid-induced apoptosis revisited: a novel role for glucocorticoid receptor translocation to the mitochondria.

@article{Sionov2006GlucocorticoidinducedAR,
  title={Glucocorticoid-induced apoptosis revisited: a novel role for glucocorticoid receptor translocation to the mitochondria.},
  author={Ronit Vogt Sionov and Shlomit Kfir and Elazar Zafrir and Orly Cohen and Yael Zilberman and Eitan Yefenof},
  journal={Cell cycle},
  year={2006},
  volume={5 10},
  pages={1017-26}
}
Recent data cast new light on the mechanisms by which glucocorticoids (GCs) elicit apoptosis of thymocytes and leukemia cells. Here we attempt to integrate recent studies by others and us, which provide a novel insight to this apoptotic process. In the last few years it was made clear that there is a tight cooperation between genomic and non-genomic effects exerted by GC receptors (GRs). GC invokes major alterations in the gene expression profile through GR-mediated transactivation and… CONTINUE READING