Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor.

@article{Helmberg1995GlucocorticoidinducedAO,
  title={Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor.},
  author={Arno Helmberg and N Auphan and Carm{\'e} Caelles and Michael Karin},
  journal={The EMBO journal},
  year={1995},
  volume={14 3},
  pages={452-60}
}
Induction of apoptosis in lymphocytes, which may account for the therapeutic effects of glucocorticoids in various diseases including leukemia, depends on the glucocorticoid receptor. However, the events leading from the activated receptor to cell lysis are not understood. A prevailing hypothesis postulates induction of so-called 'lysis genes' by the activated receptor. In this study, we show that an activation-deficient glucocorticoid receptor mutant is as effective as the wild-type receptor… CONTINUE READING

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