Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity.

@article{RamirezMontagut2006GlucocorticoidinducedTR,
  title={Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity.},
  author={Teresa Ramirez-Montagut and Andrew Z Chow and Daniel Hirschhorn-Cymerman and Theis H. Terwey and Adam A. Kochman and Sydney X. Lu and Randy C. Miles and Shimon Sakaguchi and Alan N. Houghton and Marcel R M van den Brink},
  journal={Journal of immunology},
  year={2006},
  volume={176 11},
  pages={6434-42}
}
Glucocorticoid-induced TNF receptor family related protein (GITR) is present on many different cell types. Previous studies have shown that in vivo administration of an anti-GITR agonist mAb (DTA-1) inhibits regulatory T cells (Treg)-dependent suppression and enhances T cell responses. In this study, we show that administration of DTA-1 induces >85% tumor rejection in mice challenged with B16 melanoma. Rejection requires CD4+, CD8+, and NK1.1+ cells and is dependent on IFN-gamma and Fas ligand… CONTINUE READING

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