Glucocorticoid hormone receptor mediated induction of metallothionein synthesis in HeLa cells.


HeLa cells grown in chemically defined medium lacking glucocorticoids synthesize metallothioneins, low molecular-weight heavy-metal binding proteins. Dexamethasone and hydrocortisone increase the rate of metallothionein synthesis five- to ten-fold. Maximal induction is achieved with 10(-8)M dexamethasone and 10 (-7)M hydrocortisone. Half-maximal induction… (More)


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