Glucocorticoid feedback uncovers retrograde opioid signaling at hypothalamic synapses

@inproceedings{Cusulin2013GlucocorticoidFU,
  title={Glucocorticoid feedback uncovers retrograde opioid signaling at hypothalamic synapses},
  author={Jaclyn I. Wamsteeker Cusulin and Tam{\'a}s F{\"u}zesi and Wataru Inoue and Jaideep Singh Bains},
  booktitle={Nature Neuroscience},
  year={2013}
}
Stressful experience initiates a neuroendocrine response culminating in the release of glucocorticoid hormones into the blood. Glucocorticoids feed back to the brain, causing adaptations that prevent excessive hormone responses to subsequent challenges. How these changes occur remains unknown. We found that glucocorticoid receptor activation in rodent hypothalamic neuroendocrine neurons following in vivo stress is a metaplastic signal that allows GABA synapses to undergo activity-dependent long… CONTINUE READING