Glucocorticoid feedback sensitivity and adrenocortical responsiveness in posttraumatic stress disorder.

@article{Kanter2001GlucocorticoidFS,
  title={Glucocorticoid feedback sensitivity and adrenocortical responsiveness in posttraumatic stress disorder.},
  author={Evan D. Kanter and Charles W Wilkinson and Allen D. Radant and Eric C. Petrie and Dorcas J. Dobie and Miles E. McFall and E. R. Peskind and Murray A. Raskind},
  journal={Biological psychiatry},
  year={2001},
  volume={50 4},
  pages={238-45}
}
BACKGROUND Decreased basal cortisol levels have been reported in individuals with posttraumatic stress disorder (PTSD). There is evidence for enhanced negative feedback sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis in PTSD, which could account for this, but other possible mechanisms have not been ruled out. We examined the HPA axis employing a metyrapone-cortisol infusion protocol designed to study negative feedback sensitivity. METHODS Vietnam combat trauma-exposed subjects… CONTINUE READING
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