Glucocorticoid excess induces preferential depletion of myosin in denervated skeletal muscle fibers.

@article{Rouleau1987GlucocorticoidEI,
  title={Glucocorticoid excess induces preferential depletion of myosin in denervated skeletal muscle fibers.},
  author={Guy Rouleau and George Karpati and Stirling Carpenter and Marco Antonio Soza and Stephen Prescott and Paul Holland},
  journal={Muscle & nerve},
  year={1987},
  volume={10 5},
  pages={
          428-38
        }
}
The combined effects of dexamethasone treatment (1 mg/Kg/day) plus denervation (DEX-DEN), were studied at 7, 13, and 28 days by microscopic, biochemical, and physiological techniques in plantaris and soleus muscles of adult rats. The results were compared with corresponding dexamethasone-treated (DEX) and denervated (DEN) muscles and appropriate controls. There was a significantly more marked atrophy of all fiber types in the DEX-DEN plantares at 7 and 13 days than in either DEX or DEN muscles… CONTINUE READING
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