Glucocorticoid decreases airway tone via a nongenomic pathway.

  title={Glucocorticoid decreases airway tone via a nongenomic pathway.},
  author={Chen Wang and Yi-jia Li and Yiqing Zheng and Bing Feng and Yan Liu and Ji-min Cao},
  journal={Respiratory physiology & neurobiology},
  volume={183 1},
Nocturnal asthma is associated with circadian rhythms. Although glucocorticoids have contributed to therapeutic success, the underlying mechanism has not been studied thoroughly in asthma. Here, we report that cortisol, a member of glucocorticoids, ameliorate guinea pig tracheal spasm via a nongenomic effect. We set a concentration gradient of cortisol to mimic the functional circadian fluctuation. When administrated over a threshold (150 ng/ml), cortisol could synergize with the spasmolytic… CONTINUE READING