Glucocorticoid- and protein kinase A-dependent transcriptome regulation in airway smooth muscle.

@article{Misior2009GlucocorticoidAP,
  title={Glucocorticoid- and protein kinase A-dependent transcriptome regulation in airway smooth muscle.},
  author={Anna M. Misior and Deepak A. Deshpande and Matthew J. Loza and Rodolfo M Pascual and Jason D. Hipp and Raymond B. Penn},
  journal={American journal of respiratory cell and molecular biology},
  year={2009},
  volume={41 1},
  pages={24-39}
}
Glucocorticoids (GCs) and protein kinase A (PKA)-activating agents (beta-adrenergic receptor agonists) are mainstream asthma therapies based on their ability to prevent or reverse excessive airway smooth muscle (ASM) constriction. Their abilities to regulate another important feature of asthma--excessive ASM growth--are poorly understood. Recent studies have suggested that GCs render agents of inflammation such as IL-1 beta and TNF-alpha mitogenic to ASM, via suppression of (antimitogenic… CONTINUE READING