Glucocorticoid and cAMP induction mechanisms are differentially affected by the p85gag-mos oncoprotein.

@article{Hamilton1989GlucocorticoidAC,
  title={Glucocorticoid and cAMP induction mechanisms are differentially affected by the p85gag-mos oncoprotein.},
  author={B J Hamilton and Donald B DeFranco},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 2},
  pages={597-601}
}
The inability to perceive and coordinate both internal and external signals that function to regulate cellular growth and proliferation is a hallmark of oncogenic transformation. To examine the effects of the v-mos oncogene on distinct signal transduction pathways, the 6m2 cell line was used, in which expression of the p85gag-mos oncogene, and consequently transformation, are temperature sensitive. Through the analysis of endogenous metallothionein 1 (Mt-1) gene expression in 6m2 cells, p85gag… CONTINUE READING

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