Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1.

@article{Ou2006GlucocorticoidAA,
  title={Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1.},
  author={X M Ou and Kevin Chen and Jean Chen Shih},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 30},
  pages={21512-25}
}
Monoamine oxidase (MAO) A is a key enzyme for the degradation of neurotransmitters serotonin, norepinephrine, and dopamine. There are three consensus glucocorticoid/androgen response elements and four Sp1-binding sites in the human monoamine oxidase A 2-kb promoter. A novel transcription factor R1 (RAM2/CDCA7L) interacts with Sp1-binding sites and represses MAO A gene expression. Luciferase assays show that glucocorticoid (dexamethasone) and androgen (R1881) increase MAO A promoter and… CONTINUE READING
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Sp1 Regulate Activation of MAO A Induced by Steroid Hormones

  • G. S. De Zutter, R. J. Davis
  • JULY 28,
  • 2001

The effect of R1 on GR/AR activation of MAO A in wild-type and R1-knockdown cells

  • J. Knoll, K. Magyar
  • Adv. Biochem. Psychopharmacol
  • 1972

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