Glucocorticoid actions and metabolism in pregnancy: implications for placental function and fetal cardiovascular activity.

@article{Sun1998GlucocorticoidAA,
  title={Glucocorticoid actions and metabolism in pregnancy: implications for placental function and fetal cardiovascular activity.},
  author={Kang Sun and Kaiping Yang and John R. G. Challis},
  journal={Placenta},
  year={1998},
  volume={19 5-6},
  pages={353-60}
}
The isoforms of the enzyme 11beta hydroxysteroid dehydrogenase (11betaHSD) are expressed in placental tissue and fetal membranes. The two major isoforms, 11betaHSD-1 and 11betaHSD-2, are compartmentalized discretely, and regulated differentially by steroids (oestrogen, progesterone), activators of cAMP pathway, and nitric oxide. 11BetaHSD-2 appears important in human pregnancy in regulating the amount of maternal cortisol that crosses the placenta to reach the fetal compartment. On the other… CONTINUE READING

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