Glucocorticoid Resistance and the Immune Function in the Immunodeficiency Syndrome

  title={Glucocorticoid Resistance and the Immune Function in the Immunodeficiency Syndrome},
  author={G. Norbiato and M. Bevilacqua and T. Vago and M. Clerici},
  journal={Annals of the New York Academy of Sciences},
  • G. Norbiato, M. Bevilacqua, +1 author M. Clerici
  • Published 1998
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • Abstract: Glucocorticoids, the final product of HPA axis, and their receptors (GRs) on mononuclear cells are crucial mediators in the endocrine‐immune interaction. An alteration in GRs involving a lower receptor affinity (Kd) for glucocorticoids has been found in a group of advanced AIDS patients, who developed Addisonian symptoms (weakness, weight loss, hypotension, hyponatremia, and intense mucocutaneous melanosis) in spite of hypercortisolism and normal or slightly elevated values of ACTH… CONTINUE READING
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