Glucocorticoid Generates ROS to Induce Oxidative Injury in the Hippocampus, Leading to Impairment of Cognitive Function of Rats

@inproceedings{Sato2010GlucocorticoidGR,
  title={Glucocorticoid Generates ROS to Induce Oxidative Injury in the Hippocampus, Leading to Impairment of Cognitive Function of Rats},
  author={Hiroya Sato and Takeyuki Takahashi and Kazumi Sumitani and Hirokatsu Takatsu and Shiro Urano},
  booktitle={Journal of clinical biochemistry and nutrition},
  year={2010}
}
The present study attempted to clarify whether over-secretion of glucocorticoids in the serum caused by increased hypothalamus-pituitary-adrenal activity induces oxidative stress in the rat brain, and how the stress causes the emergence of cognitive deficits. When rats were subcutaneously injected with corticosterone, lipid hydroperoxides and protein carbonyls increased markedly in the hippocampus in association with a decrease in activity of antioxidative enzymes, such as superoxide dismutase… CONTINUE READING
62 Citations
24 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 24 references

Increased F2-isoprostane levels in the rat brain and plasma caused by oxidative stress and aging, and inhibitory effect of vitamin E

  • T. Nishio, R. Miyadera, +4 authors S. Urano
  • J. Clin. Biochem. Nutr.,
  • 2006
1 Excerpt

Similar Papers

Loading similar papers…