GlucoMen Day Continuous Glucose Monitoring System: A Screening for Enzymatic and Electrochemical Interferents

@article{Lucarelli2012GlucoMenDC,
  title={GlucoMen Day Continuous Glucose Monitoring System: A Screening for Enzymatic and Electrochemical Interferents},
  author={Fausto Lucarelli and Francesco Ricci and Felice Caprio and F. Valgimigli and Cosimo Scuffi and Danila Moscone and Giuseppe Palleschi},
  journal={Journal of Diabetes Science and Technology},
  year={2012},
  volume={6},
  pages={1172 - 1181}
}
Background: While most of the common drugs with the potential to interfere with continuous glucose monitoring (CGM) systems are accessible over the counter and can be assumed by CGM patients without medical supervision, many other chemicals are frequently used to treat critically ill patients. Continuous glucose monitoring reading accuracy may also be compromised in patients characterized by abnormally high concentrations of physiological interferents. In this article, 22 species selected from… 
View on SAGE
europepmc.org
34 Citations
Background Citations
11
Methods Citations
1

Figures and Tables from this paper

34 Citations

Interference Assessment of Various Endogenous and Exogenous Substances on the Performance of the Eversense Long-Term Implantable Continuous Glucose Monitoring System

Although tetracycline and mannitol interfered with the Eversense sensor, substances frequently reported to interfere with enzymatic, electrochemical-based transcutaneous CGM systems, such as acetaminophen and ascorbic acid, did not affect Eversens readings.

Laboratory Protocol and Pilot Results for Dynamic Interference Testing of Continuous Glucose Monitoring Sensors.

An experimental in vitro setup and protocol may provide a useful method to dynamically test CGM sensors for interfering substances and may help to improve the accuracy of future CGM sensor generations.

Review—Electrochemistry and Other Emerging Technologies for Continuous Glucose Monitoring Devices

Electrochemical CGMs with a focus on sensor design and bio-compatibility, and an outlook for the future technologies, highlighting the need for innovative materials, possibility of integrating with the Internet of Things (IoT) for real-time e-health monitoring.

Minimizing the Impact of Time Lag Variability on Accuracy Evaluation of Continuous Glucose Monitoring Systems

When assessing the accuracy of a CGM system, a crucial step in data analysis is to account for time lag, which enables minimization of the apparent decline in system accuracy.

Electrochemical Glucose Biosensors for Diabetes Care

Blood glucose monitoring (BGM) is the most successful application of electrochemical biosensor technology and has motivated tremendous improvements in biology, chemistry, measurement, and fabrication…

Blood Glucose Monitoring Systems

Continuous glucose monitoring systems provide a dynamic assessment of shifting blood glucose concentrations and facilitate the making of optimal treatment decisions for the diabetic patient, and could contribute to a paradigm shift in the management of glycaemic control.

Optimising the glucose sampling performance of an intravascular microdialysisbased continuous glucose monitoring device for use in hospital settings

Aim of these trials was to optimise the performance of an intravascular microdialysis-based device under development at A. Menarini Diagnostics (Italy).

Enzyme‐Based Glucose Sensor: From Invasive to Wearable Device

Invasive and noninvasive blood glucose monitoring methods using various biofluids or blood are described, highlighting the recent progress in the development of enzyme‐based glucose sensors and their integrated systems.

Review of present method of glucose from human blood and body fluids assessment

Ex-vivo glucose sensors using micro-dialysis: importance of on-line recovery rate determination by multi-analyte infrared spectrometry

The theoretical nonlinear relationship between the relative dialysate marker concentration and glucose recovery rate was confirmed, rendering a basis for reliable blood glucose measurements and provides a straightforward correction of any dialysis recovery rate variation during patient monitoring.

References

SHOWING 1-10 OF 18 REFERENCES

Effects of drugs on glucose measurements with handheld glucose meters and a portable glucose analyzer.

Clinicians are advised to choose glucose devices carefully and interpret results cautiously when glucose measurements are performed during or after drug interventions, because package inserts for the glucose devices may not provide adequate warning information.

The chemistry of commercial continuous glucose monitors.

The analytical methodologies of the continuous glucose monitors commercialized to date are described and three minimally invasive systems employ subcutaneous amperometric sensors are described.

Toward continuous glucose monitoring with planar modified biosensors and microdialysis. Study of temperature, oxygen dependence and in vivo experiment.

A continuous glucose sensor based on wired enzyme technology -- results from a 3-day trial in patients with type 1 diabetes.

This study describes the response of 48 sensors implanted for 3 days in patients with Type 1 diabetes, finding that choice of the site of the implanted sensor or the capillary blood calibration site did not affect system accuracy.

Ex Vivo Continuous Glucose Monitoring With Microdialysis Technique: The Example of GlucoDay

The use of a glucose biosensor in conjunction with a microdialysis probe used to sample the interstitial fluid of the patient has been demonstrated to be extremely useful and advantageous for…

Intensive insulin therapy in critically ill patients.

This commentary reviews the problems of glucose measurements arising from matrix effects, interferences and the use of different assays and concludes that point-of-care testing is the best way of monitoring blood glucose.

Pre- and postoperative accuracy and safety of a real-time continuous glucose monitoring system in cardiac surgical patients: a randomized pilot study.

Although the RT-CGMS is safe and accurate according to accepted standards, there are still small aberrations, which in the opinion preclude unlimited use in its present form in a clinical setting.

In vitro, in vivo and post explantation testing of glucose-detecting biosensors: current methods and recommendations.

Intensive insulin therapy in the intensive care unit: assessment by continuous glucose monitoring

Since it was observed that insulin therapy based on discontinuous glucose measurements failed to maintain normoglycemia, it was suggested that it might be improved using online CGM, and the best available method—a posteriori calibration was used.

In Vivo Glucose Sensing

This book discusses strategies to Overcome Biological Barriers to Biosensing, and the use of Raman Spectroscopy for Noninvasive Glucose Sensing in Wound Healing Surrounding Implanted Devices.