Glucan-Based Macrophage Stimulators

  title={Glucan-Based Macrophage Stimulators},
  author={Dr David L. Williams and Antje R. M{\"u}ller and William A. Browder},
  journal={Clinical Immunotherapeutics},
Sepsis and sepsis syndrome are significant causes of morbidity and mortality in critically ill surgical patients. Despite technological and therapeutic advances in critical care, sepsis continues to be a pivotal factor in 20 to 50% of deaths in surgical intensive care units. It is clear that alternative approaches to the prevention and/or treatment of sepsis must be found. Preclinical data indicate that macrophage activation with (1 →3)-β-D-glucans will ameliorate sequelae associated with Gram… CONTINUE READING
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