Glucan-Based Macrophage Stimulators

@article{Williams2012GlucanBasedMS,
  title={Glucan-Based Macrophage Stimulators},
  author={Dr David L. Williams and Antje R. M{\"u}ller and William A. Browder},
  journal={Clinical Immunotherapeutics},
  year={2012},
  volume={5},
  pages={392-399}
}
Sepsis and sepsis syndrome are significant causes of morbidity and mortality in critically ill surgical patients. Despite technological and therapeutic advances in critical care, sepsis continues to be a pivotal factor in 20 to 50% of deaths in surgical intensive care units. It is clear that alternative approaches to the prevention and/or treatment of sepsis must be found. Preclinical data indicate that macrophage activation with (1 →3)-β-D-glucans will ameliorate sequelae associated with Gram… CONTINUE READING
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Effect of interferon gamma on infection-related death in patients with severe injuries: a randomi zed. double-blind, placebo-controlled trial

  • DJ II. Dries, GJ Jurkovick, RV Maier
  • Arch Surg
  • 1994

Randomi zed phase 1111 trial of a macrophage-specific immunomodulator (PGGglucan) in high-risk surgical patients

  • TJ Babineau, P Marcello, W Swails
  • Ann Surg
  • 1994

Fungal p-glucans modulate macrophage release of tumor necrosis factor-a in response to bacterial lipopolysaccharide

  • EJ HoffmanOA.Olson, AH Limper
  • Immunol lett
  • 1993

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