Glucagonomas of transgenic mice express a wide range of general neuroendocrine markers and bioactive peptides

@article{Rindi1991GlucagonomasOT,
  title={Glucagonomas of transgenic mice express a wide range of general neuroendocrine markers and bioactive peptides},
  author={Guido Rindi and Shimon Efrat and Mohammad A. Ghatei and Stephen R. Bloom and Enrico Solcia and Julia M P Polak},
  journal={Virchows Archiv A},
  year={1991},
  volume={419},
  pages={115-129}
}
Pancreatic tumours of transgenic mice carrying a glucagon-promoted simian virus 40 (SV40) T antigen oncogene have been analysed by histological, histochemical, ultrastructural and radioimmunological means. Seven transgenic mice were examined revealing dysplastic and neoplastic lesions in the endocrine pancreas. Four tumours were identified, one of which metastasized to periadrenal spaces and paravertebral lymph nodes. Benign tumours were composed of argyrophilic, endocrine cells reactive to a… CONTINUE READING