Glucagonoma syndrome: a review and update on treatment
@article{John2016GlucagonomaSA, title={Glucagonoma syndrome: a review and update on treatment}, author={A John and Robert A. Schwartz}, journal={Journal of the European Academy of Dermatology and Venereology}, year={2016}, volume={30} }
Glucagonoma syndrome is defined by the presence of an alpha‐cell secreting tumour of the pancreas, elevated levels of glucagon, and a characteristic rash called necrolytic migratory erythema (NME). NME is usually a specific and often initial finding of glucagonoma syndrome, but it may occur in other settings unassociated with an alpha‐cell pancreatic tumour (pseudoglucagonoma syndrome). Glucagonoma syndrome must be distinguished from pseudoglucagonoma syndrome. Prompt recognition of NME and…
63 Citations
Glucagonoma: From skin lesions to the neuroendocrine component (Review).
- MedicineExperimental and therapeutic medicine
- 2020
Increased awareness of the condition involves multidisciplinary practitioners because NME as paraneoplastic syndrome may be present for months and even years until adequate recognition and therapy; it is remitted after successful pancreatic surgery.
MANIFESTATIONS OF GLUCAGONOMA SYNDROME.
- MedicineAACE clinical case reports
- 2020
In this case, pancreatectomy and hepatic lobectomy followed by somatostatin analogue therapy was the chosen treatment strategy and adds new knowledge about glucagonoma which is important due to the low incidence of the disease and the particular characteristics of the syndrome.
Necrolytic Migratory Erythema: Complete Healing after Surgical Removal of Pancreatic Carcinoma.
- MedicineActa dermatovenerologica Croatica : ADC
- 2018
A 55-year-old female patient with a 5-year history of unrecognized cutaneous and systemic manifestations of glucagonoma syndrome without metastases is presented, and the diagnosis of glucagonsoma syndromewithout metastases was established.
Glucagonoma syndrome with severe erythematous rash
- MedicineMedicine
- 2019
Clinicians should consider the diagnosis of glucagonoma according to the typical initial symptoms, and a multidisciplinary approach is effective in patients with unresectable metastatic tumors.
Diarrhea: a missed D in the 4D glucagonoma syndrome
- MedicineAutopsy & case reports
- 2019
The case of an advanced glucagonoma with liver spread, where all these 4D symptoms occurred but a chronic secretory Diarrhea was the most relevant feature, and the patient’s impaired nutritional status limited other therapeutic approaches and he died of respiratory failure due to sepsis.
Necrolytic Migratory Erythema: A Forgotten Paraneoplastic Condition
- MedicineJournal of cutaneous medicine and surgery
- 2017
A case of a middle-aged woman seen in the authors' dermatology clinic with longstanding skin findings suggestive of NME revealing a glucagonoma, which is often the first clinical finding of an occult neuroendocrine pancreatic neoplasia is reported.
Normoglycemic glucagonoma syndrome associated with necrolytic migratory erythema
- MedicineJournal of the European Academy of Dermatology and Venereology : JEADV
- 2018
A 44-year-old male patient presented with a 4-year history of unexplained exanthema and unintentional weight loss with a mildly pruritic rash, and two low-grade neuroendocrine neoplasms consistent with glucagonoma and NME were confirmed.
Malignant transformation of glucagonoma with SPECT/CT In-111 OctreoScan features
- MedicineMedicine
- 2017
A 68-year-old woman with a pancreatic glucagonoma who had a malignant transformation, and metastases suddenly started to grow up, passed away after 4 years of treatment.
Spleen-preserving distal pancreatectomy and lymphadenectomy for glucagonoma syndrome
- MedicineMedicine
- 2019
The patient recovered uneventfully with the glucagonoma syndrome disappeared soon after surgery, and the postoperative plasma glucagon decreased to a normal level, and follow-up showed no recurrence for 5 years since the surgery.
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