Glucagon treatment of rats activates the respiratory chain of liver mitochondria at more than one site.

@article{Halestrap1987GlucagonTO,
  title={Glucagon treatment of rats activates the respiratory chain of liver mitochondria at more than one site.},
  author={A. Halestrap},
  journal={Biochimica et biophysica acta},
  year={1987},
  volume={927 2},
  pages={
          280-90
        }
}
  • A. Halestrap
  • Published 1987
  • Biology, Medicine
  • Biochimica et biophysica acta
The rate of reduction of ferricyanide in the presence and absence of antimycin and ubiquinone-1 was measured using liver mitochondria from control and glucagon treated rats. Glucagon treatment was shown to increase electron flow from both NADH and succinate to ubiquinone, and from ubiquinone to cytochrome c. 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU) was shown to inhibit the oxidation of glutamate + malate to a much greater extent than that of succinate or duroquinol. Spectral and kinetic… Expand
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