Glucagon secretion is essential for aminoacid-induced hyperfiltration in man.

  title={Glucagon secretion is essential for aminoacid-induced hyperfiltration in man.},
  author={G{\'e}rard Friedlander and F Blanchet-Benqu{\'e} and Alain Nitenberg and Christine Laborie and Roger Assan and Claude Amiel},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={5 2},
The role of glucagon as a mediator of aminoacid-induced alteration of renal haemodynamics was evaluated in man in three different protocols. In the first it was shown that the increase in glomerular filtration rate (GFR) and renal plasma flow (RPF) observed during an aminoacid infusion was prevented by the additional infusion of somatostatin (SRIF), but reproduced by a glucagon infusion in the presence of SRIF. In the second protocol it was shown that, at variance with normal subjects, six… CONTINUE READING

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