Glucagon reduces airway hyperreactivity, inflammation, and remodeling induced by ovalbumin

  title={Glucagon reduces airway hyperreactivity, inflammation, and remodeling induced by ovalbumin},
  author={Daniella Bianchi Reis Insuela and Carolina T Azevedo and Diego de S{\'a} Coutinho and Nathalia dos Santos Magalh{\~a}es and M. Montserrat Real Ferrero and Tatiana Paula Teixeira Ferreira and Cynthia Machado Cascabulho and Andr{\'e}a Henriques-Pons and Priscilla Christina Olsen and Bruno Lourenço Diaz and Patr{\'i}cia Machado Rodrigues Silva and Renato S B Cordeiro and Marco A.T. Martins and Vinicius F Carvalho},
  booktitle={Scientific Reports},
Glucagon has been shown to be beneficial as a treatment for bronchospasm in asthmatics. Here, we investigate if glucagon would prevent airway hyperreactivity (AHR), lung inflammation, and remodeling in a murine model of asthma. Glucagon (10 and 100 µg/Kg, i.n.) significantly prevented AHR and eosinophilia in BAL and peribronchiolar region induced by ovalbumin (OVA) challenge, while only the dose of 100 µg/Kg of glucagon inhibited subepithelial fibrosis and T lymphocytes accumulation in BAL and… CONTINUE READING
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Publications referenced by this paper.

The biology of glucagon and the consequences of hyperglucagonemia

N. J. Wewer Albrechtsen, R. E. Kuhre, J. Pedersen, F. K. Knop, J. J. Holst
  • Biomarkers in medicine
  • 2016

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