Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function.

@article{Srensen2006GlucagonRK,
  title={Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function.},
  author={Heidi Iskou S\orensen and Maria S{\"o}rhede Winzell and Christian Lehn Brand and Keld Fosgerau and Richard Wayne Gelling and Erica Nishimura and Bo Ahr{\'e}n},
  journal={Diabetes},
  year={2006},
  volume={55 12},
  pages={3463-9}
}
In previous studies, glucagon receptor knockout mice (Gcgr(-/-)) display reduced blood glucose and increased glucose tolerance, with hyperglucagonemia and increased levels of glucagon-like peptide (GLP)-1. However, the role of glucagon receptor signaling for the regulation of islet function and insulin sensitivity is unknown. We therefore explored beta-cell function and insulin sensitivity in Gcgr(-/-) and wild-type mice. The steady-state glucose infusion rate during hyperinsulinemic-euglycemic… CONTINUE READING