Glucagon-like peptide-2-stimulated protein synthesis through the PI 3-kinase-dependent Akt-mTOR signaling pathway.

@article{Shi2011GlucagonlikePP,
  title={Glucagon-like peptide-2-stimulated protein synthesis through the PI 3-kinase-dependent Akt-mTOR signaling pathway.},
  author={Xuemei Shi and Xiaojie Li and Yi Wang and Keying Zhang and Fuguo Zhou and Lawrence K Chan and Defa Li and Xinfu Guan},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2011},
  volume={300 3},
  pages={E554-63}
}
Glucagon-like peptide-2 (GLP-2) is a nutrient-responsive neuropeptide that exerts diverse actions in the gastrointestinal tract, including enhancing mucosal cell survival and proliferation. GLP-2 stimulates mucosal growth in vivo with an increased rate of protein synthesis. However, it was unclear whether GLP-2 can directly stimulate protein synthesis. The objective was to test critically whether GLP-2 receptor (GLP-2R) activation directly stimulates protein synthesis through a PI 3-kinase… CONTINUE READING