Glucagon-like peptide-1 stimulates human insulin promoter activity in part through cAMP-responsive elements that lie upstream and downstream of the transcription start site.

@article{Hay2005GlucagonlikePS,
  title={Glucagon-like peptide-1 stimulates human insulin promoter activity in part through cAMP-responsive elements that lie upstream and downstream of the transcription start site.},
  author={Colin W. Hay and Elaine M. Sinclair and Giovanna Bermano and Elaine Durward and Mohammad Tadayyon and Kevin Docherty},
  journal={The Journal of endocrinology},
  year={2005},
  volume={186 2},
  pages={353-65}
}
Glucagon-like peptide-1 (GLP-1) is a peptide hormone secreted from the enteroendocrine L-cells of the gut and which acts primarily to potentiate the effects of glucose on insulin secretion from pancreatic beta-cells. It also stimulates insulin gene expression, proinsulin biosynthesis and affects the growth and differentiation of the islets of Langerhans. Previous studies on the mechanisms whereby GLP-1 regulates insulin gene transcription have focused on the rat insulin promoter. The aim of… CONTINUE READING

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