Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway.

@article{Gupta2010GlucagonlikePR,
  title={Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway.},
  author={Nitika Gupta and Jamie Eugene Mells and Richard M. Dunham and Arash Grakoui and Jeffrey A Handy and Neeraj Saxena and Frank A Anania},
  journal={Hepatology},
  year={2010},
  volume={51 5},
  pages={
          1584-92
        }
}
UNLABELLED Glucagon-like peptide 1 (GLP-1) is a naturally occurring peptide secreted by the L cells of the small intestine. GLP-1 functions as an incretin and stimulates glucose-mediated insulin production by pancreatic beta cells. In this study, we demonstrate that exendin-4/GLP-1 has a cognate receptor on human hepatocytes and that exendin-4 has a direct effect on the reduction of hepatic steatosis in the absence of insulin. Both glucagon-like peptide 1 receptor (GLP/R) messenger RNA and… CONTINUE READING
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