Glucagon-like peptide 1 receptor agonist or bolus insulin with optimized basal insulin in type 2 diabetes.

@article{Diamant2014GlucagonlikeP1,
  title={Glucagon-like peptide 1 receptor agonist or bolus insulin with optimized basal insulin in type 2 diabetes.},
  author={Michaela Diamant and Michael A Nauck and Rimma M. Shaginian and James Malone and Simon Cleall and Matthew Reaney and Danielle de Vries and Byron J Hoogwerf and Leigh A Macconell and Bruce H. R. Wolffenbuttel},
  journal={Diabetes care},
  year={2014},
  volume={37 10},
  pages={
          2763-73
        }
}
OBJECTIVE Mealtime insulin is commonly added to manage hyperglycemia in type 2 diabetes when basal insulin is insufficient. However, this complex regimen is associated with weight gain and hypoglycemia. This study compared the efficacy and safety of exenatide twice daily or mealtime insulin lispro in patients inadequately controlled by insulin glargine and metformin despite up-titration. RESEARCH DESIGN AND METHODS In this 30-week, open-label, multicenter, randomized, noninferiority trial… CONTINUE READING

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