Glucagon-like peptide-1 receptor agonism improves metabolic, biochemical, and histopathological indices of nonalcoholic steatohepatitis in mice.

@article{Trevaskis2012GlucagonlikePR,
  title={Glucagon-like peptide-1 receptor agonism improves metabolic, biochemical, and histopathological indices of nonalcoholic steatohepatitis in mice.},
  author={James L Trevaskis and Peter S Griffin and Carrie Wittmer and Brent A Neuschwander-Tetri and Elizabeth M. Brunt and Carrie S. Dolman and Mary R Erickson and James Napora and David G. Parkes and Jonathan David Roth},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2012},
  volume={302 8},
  pages={G762-72}
}
These preclinical studies aimed to 1) increase our understanding the dietary induction of nonalcoholic steatohepatitis (NASH), and, 2) further explore the utility and mechanisms of glucagon-like peptide-1 receptor (GLP-1R) agonism in NASH. We compared the effects of a high trans-fat (HTF) or high lard fat (HLF) diet on key facets of nonalcoholic fatty liver disease (NAFLD)/NASH in Lep(ob)/Lep(ob) and C57BL6J (B6) mice. Although HLF-fed mice experienced overall greater gains in weight and… CONTINUE READING
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