Glucagon-like peptide-1 prevents beta cell glucolipotoxicity

  title={Glucagon-like peptide-1 prevents beta cell glucolipotoxicity},
  author={Jean H. Buteau and Wissal El-Assaad and Christopher J Rhodes and Lawrence Rosenberg and Erik Joly and Marc Prentki},
We have provided evidence that glucagon-like peptide-1, a potential therapeutic agent in the treatment of diabetes, activates phosphatidylinositol-3 kinase/protein kinase B signalling in the pancreatic beta cell. Since this pathway promotes cell survival in a variety of systems, we tested whether glucagon-like peptide-1 protects beta cells against cell death induced by elevated glucose and/or non-esterified fatty acids. Human islets and INS832/13 cells were cultured at glucose concentrations of… CONTINUE READING