Glucagon-like peptide-1 preserves coronary microvascular endothelial function after cardiac arrest and resuscitation: potential antioxidant effects.

@article{Dokken2013GlucagonlikePP,
  title={Glucagon-like peptide-1 preserves coronary microvascular endothelial function after cardiac arrest and resuscitation: potential antioxidant effects.},
  author={Betsy B. Dokken and Charles V. Piermarini and Mary K. Teachey and Michael T Gura and Christian J. Dameff and Brian D. Heller and Jonida Krate and Aeen M. Ashgar and Lauren Querin and Jennifer L. Mitchell and Ronald Willard Hilwig and Karl B. Kern},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2013},
  volume={304 4},
  pages={H538-46}
}
Glucagon-like peptide-1 (GLP-1) has protective effects in the heart. We hypothesized that GLP-1 would mitigate coronary microvascular and left ventricular (LV) dysfunction if administered after cardiac arrest and resuscitation (CAR). Eighteen swine were subjected to ventricular fibrillation followed by resuscitation. Swine surviving to return of spontaneous circulation (ROSC) were randomized to receive an intravenous infusion of either human rGLP-1 (10 pmol·kg(-1)·min(-1); n = 8) or 0.9% saline… CONTINUE READING
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