Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis.

@article{Lee2007GlucagonlikePG,
  title={Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis.},
  author={Young-Sun KimᆞJung-Hwa Lee and Seungjin Shin and Toshikatsu Shigihara and Eunsil Hahm and Meng-Ju Liu and Jaeseok Han and Ji-Won Yoon and Hee-Sook Jun},
  journal={Diabetes},
  year={2007},
  volume={56 6},
  pages={1671-9}
}
Long-term treatment with glucagon-like peptide (GLP)-1 or its analog can improve insulin sensitivity. However, continuous administration is required due to its short half-life. We hypothesized that continuous production of therapeutic levels of GLP-1 in vivo by a gene therapy strategy may remit hyperglycemia and maintain prolonged normoglycemia. We produced a recombinant adenovirus expressing GLP-1 (rAd-GLP-1) under the cytomegalovirus promoter, intravenously injected it into diabetic ob/ob… CONTINUE READING
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