Glucagon-like peptide-1 evokes action potentials and increases cytosolic Ca2+ in rat nodose ganglion neurons.

@article{Kakei2002GlucagonlikePE,
  title={Glucagon-like peptide-1 evokes action potentials and increases cytosolic Ca2+ in rat nodose ganglion neurons.},
  author={Masafumi Kakei and Toshihiko Yada and Atsushi Nakagawa and Hajime Nakabayashi},
  journal={Autonomic neuroscience : basic & clinical},
  year={2002},
  volume={102 1-2},
  pages={39-44}
}
We previously reported that the intraportal appearance of glucagon-like peptide-1 (GLP-1) facilitates the afferent activity (the spike discharge firing rate) of the rat hepatic vagus in a dose-dependent fashion. To examine whether GLP-1 directly activates single neurons isolated from the rat nodose ganglion, GLP-1-induced changes of the membrane potential and cytosolic-free Ca2+ concentration ([Ca2+]i) in the cells were measured using whole-cell patch-clamp and microfluorometric techniques… CONTINUE READING