Glucagon-like peptide-1 does not mediate amylase release from AR42J cells.

  title={Glucagon-like peptide-1 does not mediate amylase release from AR42J cells.},
  author={Jie Zhou and Chahrzad Montrose-Rafizadeh and Andrzej M. Janczewski and Marco A Pineyro and Steven J. Sollott and Yingchun Wang and Josephine M. Egan},
  journal={Journal of cellular physiology},
  volume={181 3},
In this study, AR42J pancreatic acinar cells were used to investigate if glucagon-like peptide-1 (GLP-1) or glucagon might influence amylase release and acinar cell function. We first confirmed the presence of GLP-1 receptors on AR42J cells by reverse trasncriptase-polymerase chain reaction (RT-PCR), Western blotting, and partial sequencing analysis. While cholecystokinin (CCK) increased amylase release from AR42J cells, GLP-1, alone or in the presence of CCK, had no effect on amylase release… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…