Glucagon-like peptide 1 and peptide YY are in separate storage organelles in enteroendocrine cells

@article{Cho2014GlucagonlikeP1,
  title={Glucagon-like peptide 1 and peptide YY are in separate storage organelles in enteroendocrine cells},
  author={Hyun-jung Cho and Eliza S. Robinson and Leni Rose Rivera and Paul J. McMillan and Adam Gareth Testro and Mehrdad Nikfarjam and David M. Bravo and John Barton Furness},
  journal={Cell and Tissue Research},
  year={2014},
  volume={357},
  pages={63-69}
}
A sub-group of enteroendocrine cells (L cells) release gastrointestinal hormones, GLP-1 and PYY, which have different but overlapping physiological effects, in response to intraluminal nutrients. Whilst their release profiles are not identical, how the plasma levels of these two hormones are differentially regulated is not well understood. We investigate the possibility that GLP-1 and PYY are in separate storage vesicles. In this study, the subcellular location of GLP-1 and PYY storage… CONTINUE READING
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Endogenous PYYandGLP-1mediate L-glutamine responses in intestinal mucosa

  • S Joshi, IR Tough
  • CoxHM
  • 2013

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