Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation.

@article{Shiraishi2012GlucagonlikeP,
  title={Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation.},
  author={Daisuke Shiraishi and Yukio Fujiwara and Yoshihiro Komohara and Hiroshi Mizuta and Motohiro Takeya},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={425 2},
  pages={304-8}
}
It is known that glucagon-like peptide-1 (GLP-1) is a hormone secreted postprandially from the L-cells of the small intestine and regulates glucose homeostasis. GLP-1 is now used for the treatment of diabetes because of its beneficial role against insulin resistance. The GLP-1 receptor (GLP-1R) is expressed on many cell types, including macrophages, and GLP-1 suppresses the development of atherosclerosis by inhibiting macrophage function. However, there have so far been few studies that have… CONTINUE READING

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