Glucagon-like peptide-1: a potent regulator of food intake in humans.

  title={Glucagon-like peptide-1: a potent regulator of food intake in humans.},
  author={J P Gutzwiller and Burkhard G{\"o}ke and Juergen Drewe and P. Llody Hildebrand and Silvia Ketterer and Daniel Handschin and Ralph Winterhalder and David Conen and Ch. Beglinger},
  volume={44 1},
BACKGROUND/AIMS Studies in animals suggest a physiological role for glucagon-like peptide-1-(7-36)-amide (GLP-1) in regulating satiety. The role of GLP-1 in regulating food intake in man has, however, not been investigated. Subjects-Sixteen healthy male subjects were examined in a double blind placebo controlled fashion. METHODS The effect of graded intravenous doses (0, 0.375, 0.75, and 1.5 pmol/kg/min) of synthetic human GLP-1 on food intake and feelings of hunger and satiety was tested in… CONTINUE READING