Glucagon-like peptide 1, insulin, sensory neurons, and diabetic neuropathy.

  title={Glucagon-like peptide 1, insulin, sensory neurons, and diabetic neuropathy.},
  author={Michelle Kan and Guifang Guo and Bhagat Phool Singh and Vandana Singh and Douglas W Zochodne},
  journal={Journal of neuropathology and experimental neurology},
  volume={71 6},
Like insulin, glucagon-like peptide 1 (GLP-1) may have direct trophic actions on the nervous system, but its potential role in supporting diabetic sensory neurons is uncertain. We identified wide expression of GLP-1 receptors on dorsal root ganglia sensory neurons of diabetic and nondiabetic mice. Exendin-4, a GLP-1 agonist, increased neurite outgrowth of adult sensory neurons in vitro. To determine the effects ofexendin-4 in comparison with continuous low- or high-dose insulin in vivo, we… CONTINUE READING