Glucagon-like peptide (GLP)-1 and leptin concentrations in obese patients with Type 2 diabetes mellitus.

@article{Mannucci2000GlucagonlikeP,
  title={Glucagon-like peptide (GLP)-1 and leptin concentrations in obese patients with Type 2 diabetes mellitus.},
  author={Edoardo Mannucci and Agostino Ognibene and Francesco Cremasco and Gianluca Bardini and A Mencucci and E Pierazzuoli and Silvia Ciani and Alessandra Fanelli and Gianni Messeri and Carlo Maria Rotella},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  year={2000},
  volume={17 10},
  pages={713-9}
}
AIMS To assess differences in circulating leptin and glucagon-like peptide (GLP)-1 concentrations before and after an oral glucose load, in euglycaemic and isoinsulinaemic conditions, between obese patients with and without Type 2 diabetes mellitus. METHODS Ten male obese (body mass index (BMI) > 30 kg/m2) patients with Type 2 diabetes and 20 matched non-diabetic subjects were studied. Leptin, GLP-1(7-36)amide and GLP-1(7-37) concentrations were measured 0, 30, 60, and 90 min after a 50-g… CONTINUE READING