Glucagon-induced stimulation of 2-oxoglutarate metabolism in mitochondria from rat liver.

@article{Siess1978GlucagoninducedSO,
  title={Glucagon-induced stimulation of 2-oxoglutarate metabolism in mitochondria from rat liver.},
  author={E. A. Siess and Otto H. Wieland},
  journal={FEBS letters},
  year={1978},
  volume={93 2},
  pages={
          301-6
        }
}
  • E. A. Siess, Otto H. Wieland
  • Published 1978
  • Medicine, Biology
  • FEBS letters
  • Since the discovery [ 1 ] that liver mitochondria isolated from glucagon-treated rats show an increased rate of pyruvate carboxylation, evidence for mitochondrial action(s) of this hormone is growing. In addition to the effects on pyruvate metabolism [l-7] glucagon administration has been demonstrated to increase mitochondrial respiration [5,7-l 11, ATP formation [7,10,12], ATPase activity and K’ uptake [ 131, citrulline formation [6] , hydroxyl ion concentration [7,9] and membrane potential [7… CONTINUE READING