Glucagon-induced inhibition of feeding is impaired by hepatic portal alloxan injection.

@article{Ritter1986GlucagoninducedIO,
  title={Glucagon-induced inhibition of feeding is impaired by hepatic portal alloxan injection.},
  author={Sue Ritter and Steven Weatherford and Shane Stone},
  journal={The American journal of physiology},
  year={1986},
  volume={250 4 Pt 2},
  pages={R682-90}
}
Subdiabetogenic doses of alloxan injected into the hepatic portal vein of rats abolished glucagon-induced inhibition of feeding (glucagon satiety) both in daytime tests using a palatable food and in nighttime tests using their standard pelleted diet. In contrast, inhibition of food intake by cholecystokinin and epinephrine and stimulation of feeding by 2-deoxy-D-glucose were not impaired by alloxan. Alloxan-induced deficits in glucagon satiety did not appear to result from generalized… CONTINUE READING