Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in α-cell differentiation, glucagon biosynthesis and secretion.

@article{Gosmain2011GlucagonGE,
  title={Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in α-cell differentiation, glucagon biosynthesis and secretion.},
  author={Yvan Gosmain and Claire Cheyssac and Mounia Heddad Masson and Charna Dibner and Jacques Philippe},
  journal={Diabetes, obesity & metabolism},
  year={2011},
  volume={13 Suppl 1},
  pages={31-8}
}
The glucagon gene is expressed in α-cells of the pancreas, L cells of the intestine and the hypothalamus. The determinants of the α-cell-specific expression of the glucagon gene are not fully characterized, although Arx, Pax6 and Foxa2 are critical for α-cell differentiation and glucagon gene expression; in addition, the absence of the β-cell-specific… CONTINUE READING