Glucagon degradation in isolated rat hepatocytes: effect of ammonium chloride and chloroquine.

@article{Canivet1981GlucagonDI,
  title={Glucagon degradation in isolated rat hepatocytes: effect of ammonium chloride and chloroquine.},
  author={Bertrand Canivet and Phillip Gorden and J. Carpentier and Lelio Orci and Pierre Freychet},
  journal={Molecular and cellular endocrinology},
  year={1981},
  volume={23 3},
  pages={311-20}
}
It has recently been shown that, when [125I]glucagon is incubated with isolated rat hepatocytes at 37 degrees, the radiolabeled material is progressively internalized by the cell and is found to associate preferentially with lysosome-like structures. To assess the role of this process in the degradation of the hormone, the degradation of [125I]glucagon by… CONTINUE READING