Glucagon and regulation of glucose metabolism.

@article{Jiang2003GlucagonAR,
  title={Glucagon and regulation of glucose metabolism.},
  author={Guoqiang Jiang and Bei B. Zhang},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2003},
  volume={284 4},
  pages={
          E671-8
        }
}
  • G. Jiang, Bei B. Zhang
  • Published 2003
  • Medicine
  • American journal of physiology. Endocrinology and metabolism
As a counterregulatory hormone for insulin, glucagon plays a critical role in maintaining glucose homeostasis in vivo in both animals and humans. To increase blood glucose, glucagon promotes hepatic glucose output by increasing glycogenolysis and gluconeogenesis and by decreasing glycogenesis and glycolysis in a concerted fashion via multiple mechanisms. Compared with healthy subjects, diabetic patients and animals have abnormal secretion of not only insulin but also glucagon. Hyperglucagonemia… Expand
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References

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TLDR
Despite a total absence of glucagon receptors, mice in which the glucagon receptor was inactivated maintained near-normal glycemia and normal lipidemia, in the presence of circulating glucagon concentrations that were elevated by two orders of magnitude. Expand
Glucagon physiology and pathophysiology in the light of new advances
  • R. Unger
  • Biology, Medicine
  • Diabetologia
  • 2004
TLDR
It now appears that α cells can respond directly to hyperglycaemia in the absence of insulin and β cells, but that antecedent hyperglyCAemia masks or attenuates this response. Expand
Evidence for a Major Role for Glucagon in Regulation of Plasma Glucose in Conscious, Nondiabetic, and Alloxan-Induced Diabetic Rabbits
TLDR
Glucagon is an important regulator of postabsorbtive glucose production in normal rabbits and plays an important role in the maintenance of hyperglycemia in ALX-induced diabetic rabbits. Expand
Effects of small changes in glucagon on glucose production during a euglycemic, hyperinsulinemic clamp.
TLDR
Since glucagon often declines during a euglycemic hyperinsulinemic clamp, and since small changes in glucagon can have marked effects on the suppression of hepatic glucose output even in the presence of high insulin levels, changes in glucose should be considered when conclusions regarding hepatic insulin sensitivity are being drawn. Expand
Role of Liver in Pathophysiology of NIDDM
TLDR
Preliminary data suggest that in the postprandial state increased gluconeogenesis represents the primary mechanism responsible for impaired suppression of hepatic glucose production in non-insulin-dependent diabetes mellitus. Expand
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TLDR
It is demonstrated that a glucagon receptor antagonist can substantially reduce blood glucose levels in diabetic animals without addition of exogenous insulin. Expand
Hyperglucagonemia and blood glucose regulation in normal, obese and diabetic subjects.
TLDR
The findings suggest the primary role of insulin deficiency in the diabetogenic action of glucagon is suggested, and that glucagon in the insulin-deprived patient can worsen the diabetic state. Expand
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TLDR
It is concluded that in normal volunteers, neither hyperglucagonemia nor the combination of hyperglUCagonemia and increased substrate availability alters the autoregulation of EGP. Expand
Minimal Increases in Glucagon Levels Enhance Glucose Production in Man with Partial Hypoinsulinemia
TLDR
It is concluded that, in man moderately deprived of insulin, even a marginal change in glucagon level induces a long-lasting hyperglycemia. Expand
Failure of glucagon suppression contributes to postprandial hyperglycaemia in IDDM
TLDR
It is demonstrated that lack of postprandial suppression of glucagon, by increasing hepatic glucose release, contributes to hyperglycaemia in subjects with IDDM. Expand
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