Glucagon and forskolin have dual effects upon islet cell electrical activity.

@article{Ikeuchi1984GlucagonAF,
  title={Glucagon and forskolin have dual effects upon islet cell electrical activity.},
  author={Masatoshi Ikeuchi and Daniel L. Cook},
  journal={Life sciences},
  year={1984},
  volume={35 6},
  pages={
          685-91
        }
}
We have investigated the effects of glucagon and forskolin upon pancreatic islet cell electrical activity using intracellular recordings from single mouse islets. Glucagon (0.1-2.0 microM) and forskolin (0.5-5.0 microM), both adenylate cyclase activators, potentiated glucose (200 mg/dl)-induced electrical activity. In the steady-state, islet cells have cyclic electrical activity with periodically recurring "plateau" depolarizations (with superimposed Ca++ action potentials) separated by silent… CONTINUE READING