Glucagon acutely inhibits but chronically activates Na(+)/H(+) antiporter 3 activity in OKP cells.

@article{Amemiya2002GlucagonAI,
  title={Glucagon acutely inhibits but chronically activates Na(+)/H(+) antiporter 3 activity in OKP cells.},
  author={Morimasa Amemiya and Eiji Kusano and Shigeaki Muto and Kaoru Tabei and Yasuhiro Ando and Robert J. Alpern and Yasushi Asano},
  journal={Experimental nephrology},
  year={2002},
  volume={10 1},
  pages={26-33}
}
BACKGROUND We previously found that the Na(+)/H(+) exchanger 3 (NHE3) is localized in the apical membrane of the rat renal proximal tubule and thick ascending limb of Henle. In the present study, we examined the direct effect of glucagon on the opossum kidney P (OKP) cell Na(+)/H(+) antiporter, encoded by NHE3. METHODS Na(+)/H(+) antiporter activity was measured as the rate of cell pH recovery from an acid load using 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein. Northern blot and Western… CONTINUE READING

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